Breath Analysis for Disease Diagnosis
- Non-invasive breath sampling
- Humidity independent quantitative measurement of volatile and semi-volatile organic compounds at sub-ppt limits of detection
- Reproducible and robust breath measurements
- Real-time result reporting
- Temperature controlled interface for efficient transfer of lower volatility compounds
- Continuous transfer line flushing for active inhalation and contamination prevention
- Integrated flow measurement
- VocusBREATHE software with automated breath detection
Analysis of Exhaled Breath for Disease Diagnosis
In addition to water vapor, nitrogen, oxygen, and carbon dioxide, breath is comprised of a variety of organic molecules that are often present at mixing ratio of parts-per-trillion. These endogenously produced organic compounds, known as metabolites, circulate in the body’s bloodstream and reflect metabolic and biochemical processes. Using mass-spectrometry, breath metabolites are used as biomarkers to create breath fingerprints for the identification of various respiratory and infectious diseases.
Due to high-relative humidity, chemical complexity, and fast, dynamic changes occurring during exhalation, breath is notoriously challenging to sample and analyze. Humidity independent quantification that is fast, sensitive, and robust is a requirement for conducting disease detection via breath analysis.
Real-time, Ultra-sensitive Quantification of Biomarkers Found in Breath with the Vocus CI-TOF and Vocus Breathe
- Rapid single digit sub-ppt detection of metabolites found in breath
- VocusBREATHE software provides intuitive, easy-to-use operation
- Customized breath inlet for non-invasive sample collection, featuring a disposable mouthpiece, check valve, and zero-air flush for reduced contamination risk
Screenshot from VocusBREATHE demonstrating selectivity for defined compounds with real-time analysis.
Diagnostic and Disease Research Using the Vocus CI-TOF
- High-mass resolving power for identification and quantification of breath metabolites in real-time with extreme sensitivity
- Sub parts-per-trillion limit of detection
- Humidity independent measurement
- Optional automated reagent ion switching for expanded range of detectable compounds providing higher chemical specificity and reduced fragmentation
This figure demonstrates the real-time measurement of four successive exhalations sampled directly via the breath inlet to the Vocus CI-TOF analyzer. The compounds depicted are displayed directly in parts-per-billion concentrations per volume and represent some of the most abundant VOCs found in human breath. This figure illustrates the fast, reproducible, and humidity independent response of the Vocus CI-TOF for only 4 molecules, whereas hundreds of other VOCs are quantitatively measured for every exhalation.
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