Resolving Isomeric Lipids and Metabolites

Lipidomics and metabolomics are particularly difficult analytical challenges due to the number of important isomeric species that are known or postulated in biological samples. Current separation and identification techniques are too often insufficiently powerful, slow or ambiguous. Many of the isomers, especially for lipids (e.g. position of the acyl chain, position of the double bond or double bond geometry) differ by less than 1% in collision cross section – and can still be baseline separated by the IMS-TOF. The same level of performance is maintained in complex biological mixtures.