Matthew P. Sullivan, Richard L. Kingston,David C. Goldstone & Christian G. Hartinger, University of Auckland, Australia Michael Groessl, TOFWERK, Switzerland… Read More »
Probing Protein Conformations
Over the last decade, numerous papers have reported IMS-MS investigations of biomolecules, especially proteins. In these studies, IMS-MS is used to probe the protein conformations as well as the composition, stoichiometry, and arrangement of units in biomolecular complexes. Yet, the majority of these studies were conducted either on drift-tube IMS instruments that do not operate under low-field conditions or on travelling wave IMS (TWAVE or TWIMS) instruments. Use of such instruments can lead to artifacts due to collisionally-induced heating and imprecise measurements of collision cross sections.
The TOFWERK IMS-TOF is a drift-tube based IMS-MS instrument that operates under low-field conditions with a high pressure- and temperature-controlled IMS cell. This ensures that native conditions are preserved during the ion mobility separation. Additionally, the IMS-TOF exhibits superior ion mobility resolution, thus allowing deeper insight into the conformational diversity of biomolecules.
This IMS-TOF poster from ASMS 2016 demonstrates the capabilities and benefits of our high resolution drift-tube IMS for the analysis of peptide and… Read More »
Over the last decade, numerous papers have reported IMS-MS investigations of biomolecules, especially proteins. In these studies, IMS-MS is used… Read More »
IMS-MS was again one of the most prominent topics at this year’s German Society for Mass Spectrometry (DGMS) meeting. For… Read More »