Stijn J. M. Van Malderen, Brecht Laforce, Thibaut Van Acker, Charlotte Nys, Maarten De Rijcke, Riet De Rycke, Michiel De… Read More »
Elemental Imaging of Biological Tissue
2D and 3D mass spectral imaging of biological tissue is a rapidly developing field. Knowledge of the distribution of essential major (P, S) and trace elements (K, Na, Fe, Zn, etc.) as well as toxic metals within tissue samples is instrumental to toxicology studies, cancer research, drug development, neurology and biology. The ability to quantify species in the ppb to low ppm range is a major strength of laser ablation inductively-coupled plasma mass spectrometry (LA-ICP-MS) imaging. In addition to analyzing essential metals and heteroatoms (P and S), ICP-MS can also be used for imaging and quantification of biomolecules, if labeled with specific element tags. The combination of the icpTOF with fast-washout laser ablation systems enables high-resolution, multi-elemental imaging of metals and nanoparticles in tissue at unprecedented speed.