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All the elements. All the time.

All-element, high-resolution detection for single particles, individual cells, and laser ablation imaging

TOFpilot Software

Integrated Control Software for the icpTOF

TOFpilot Instrument Control & Automated Tuning: Laser Ablation, Single-Particle Analysis, and Liquid Solution Analysis
TOFpilot software greatly simplifies the workflow for the user by integrating control of the icpTOF with different sample introduction systems, such as laser ablation systems, single-particle, or autosamplers for solution analysis. TOFpilot operates on a module-basis which allows the user to set up different workflow sequences.

TOFpilot Videos


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TOFPilot Webinar

This webinar presents an overview of the software and discusses the main sequence workflows including plasma startup, instrument tuning (manual or automated), liquid solution analysis, single particle analysis, and laser ablation imaging (including real-time display).


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TOFpilot Real-Time Laser Ablation Imaging

In this video, real-time laser ablation imaging with the icpTOF is demonstrated. Laser ablation images can be viewed within TOFpilot in real-time, and different isotope channels and color schemes can be selected.

Explore the TOFPilot Interface


Instrument Control & Tuning

From sample introduction, ion optics, CCT cell, to TOF parameters, TOFpilot seamlessly controls all operational instrument parameters within one program. The layout of the different functional blocks of settable parameters is fully configurable to the user’s requirements.

Instrument tuning is performed either manually through access to the instrument parameters, or through autotuning modules. Autotuning of detector sensitivity, ICP, and ion optics are provided at this stage. Tune settings are saved with a fully documented history of parameter changes.


Laser Ablation Imaging

The entire laser ablation process, including communication of TOFpilot with the laser software allows geometry information from the analysis ablation patterns to be received. TOFpilot displays a live preview of the laser ablation image during acquisition, allowing to quickly assess analysis quality. All relevant laser parameters, ablation patterns and operational instrument metadata is saved alongside the analysis data in one data file.


Routine Liquid Analysis

The Liquid –External Calibration module in TOFpilot allows setup of measurement sequences containing calibration standards and samples with unknown concentration. Quantification is done automatically after building and fitting of the calibration curve. TOFpilot simplifies the workflow for routine analysis and is compatible with autosamplers for fast and automated sample introduction.


Single Particle/Cell Analysis

TOFpilot is equipped with a particle analysis module, which allows for screening and quantification of particles. After measurements, the data is processed directly for particle number concentrations and particle mass distributions. Quantification is based on the method developed by Pace et al. (H. E. Pace, N. J. Rogers, C. Jarolimek, V. A. Coleman, C. P. Higgins, J. F. Ranville. Anal. Chem., 2011, 83, 9361-9369) using liquid standards for calibration and the particle size method for the determination of the transport efficiency. All results are summed in a report and are exported as csv-files to facilitate further post-processing in third-party software. Note that this module may also be used for single cell analysis.


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