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icpTOF Excels in Single-Particle ICP-MS Comparison Study

single particle analysis

Versailles Project on Advanced Materials and Standards (VAMAS) Interlaboratory Study on Measuring the Number Concentration of Colloidal Gold Nanoparticles 

Minelli et al. 
Nanoscale
DOI: 10.1039/D1NR07775A  

In this work, Minelli and a large group of international co-workers present an interlaboratory study for the analysis of colloidal nanoparticles. Specifically, the particle number concentration of 30 nm gold particles was to be determined using different methods, including single particle inductively coupled plasma mass spectrometry (spICP-MS). The aim of the study was to provide quantitative data to evaluate the repeatability and reproducibility of different methods for the measurement of number concentration of model nanoparticle systems following a common measurement protocol. 

The number concentration value obtained with the icpTOF 2R was within uncertainty of the reference value, plotting near the middle of the distribution of measured values. Thus, the icpTOF has been shown once more to be a valid analytical tool for the analysis of single particles.