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Webinar: GC meets ecTOF- New Capabilities for Compound Identification by Mass Spectrometry

ecTOF Webinar

Webinar Overview

In this webinar, TOFWERK and our French sales parter, Chemlys, introduce the ecTOF, TOFWERK’s newest development for compound identification by mass spectrometry.

For decades, gas chromatography (GC) in combination with electron ionization (EI) mass spectrometry (MS) has been the method of choice for targeted and suspect screening analysis of volatile and semi-volatile compounds. The standard method of applying 70 eV electrons offers nonselective ionization with high efficiency and produces characteristic, reproducible compound fragmentation patterns. These allow for a straightforward database matching and provide valuable structural information to further confirm the molecules of interest. This has made EI the unmatched gold standard ionization for GC-MS analysis.

In nontarget analysis (NTA) and for high confidence compound identification however, instrumentational requirements are more elaborate due to the lack of information on the analytes prior to the analysis – in these cases molecular ion information is required. Unfortunately, the extensive fragmentation following the 70 eV EI process is often results in the loss of this required molecular ion information. For compound identification and NTA, especially when a compound confirmation via standard analysis is not available, the use of EI alone is not sufficient.

The TOFWERK ecTOF offers a unique solution to this type of complex analysis problem. The ecTOF provides robust GC-MS analysis using simultaneous electron and chemical ionization. TOFWERK’s extensive knowledge of chemical ionization opens the opportunity to a wide range of special CI sources and reagents, depending on the analysis needs. The ecTOF solution therefore offers parallel generation of molecular ion information via CI next to the structural information of conventional EI. Therefore, identification confidence is increased and non-targeted analysis methods using gas chromatography are greatly improved.

Key Discussion Points

  1. Introduction of the ecTOF technology
  2. ecTOF features and performance, including different chemical Ionization (CI) options
  3. Example applications with focus on compound identification
  4. Workflows and data post processing

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Webinar Presenter

Dr. Sonja Klee has over 15 years of experience in mass spectrometric development and applications. She received her doctorate in physical chemistry at the University of Wuppertal (Germany) on the research of chemical ionization mechanisms and ion transfer development for atmospheric pressure interface mass spectrometer. Sonja is currently ecTOF product manager at TOFWERK in Thun, Switzerland.  Her work focuses on the development and commercialization of this newly developed mass spectrometer that offers simultaneous electron and chemical ionization TOFMS detection – all in one instrument.

Scott Campbell is co-founder of SpectalWorks and his work focuses on translating end user requirements from MS scientists into specifications for the software team. With over 25 years of experience in this field, Scott has been the technical lead in projects ranging from designing MS data systems with instrument control to the development of programming interfaces (API) that allow third party developers to interface their software with MS platforms. He is passionate about delivering the best solution to increase productivity and reduce overheads within the laboratory. Prior to SpectralWorks, Scott was Software Manager for ThermoFisher Scientific in Manchester, UK. Scott received a bachelor’s degree in Computer Science from the University of Stirling, Scotland. He is a professional member of the British Computer Society and a registered IT Technician.

Marion Guichard is co-founder of Chemlys, a french company specializing in gas analysis. After years of sales activities in the field offering custom analytical solutions for gas analysis, her current work focuses on the development of Chemlys and the management of partnerships. Chemlys is a value-added reseller of major manufacturers with a high experience in gas sampling design and conception. It offers complete analytical solutions including training and services.