一台可同时测量所有同位素的电感耦合等离子体质谱仪（ICP-MS
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概述
icpTOF的优越性能
icpTOF电感耦合等离子体-飞行时间质谱耦合了Thermo Scientific公司的 iCAP RQ平台（包含离子源和真空接口）和TOFWERK高性能飞行时间质谱分析仪。iCAP RQ平台提供了多类型的样品进样方式，高强度并稳固的ICP，更加简单的椎体和离子电镜维护程序和Q-cell科技。飞行时间质谱分析仪在保证跟四级管（QMS）同等灵敏度的同时，为icpTOF增加了快速全谱分析，更宽的线性动态范围和高达6000的质量分辨率。鉴于其快速全谱图采集和所有元素同位素的同步分析，icpTOF是单颗粒多元素分析和快速激光蚀刻成像的理想检测器。- All the elements. All the time. icpTOF记录全谱图以提供回溯分析,因此 您不会错过任何分析物或干扰信号。
- 高质量分辨率 icpTOF 2R高达6000的质量分辨率让排除干扰离子更加容易。
- 精确的同位素比率 icpTOF可同时测量所有同位素,从而最大程度上消除离子源和进样过程扰动对测量结果的影响。分析精度趋近于统计限制。
- 高速检测 icpTOF每隔30微秒就可记录一张全谱图,使其成为快速瞬态信号(如单个纳米颗粒,流体包裹体和单激光脉冲烧蚀)的最佳检测器。
规格
icpTOF和icpTOF 2R
icpTOF和icpTOF 2R 耦合了Thermomo Scientific公司的 iCAP RQ平台（包含离子源和真空接口）和TOFWERK高性能飞行时间质谱分析仪。icpTOF 2R搭配一款更长的飞行时间模块，提供高达6000的质量分辨率。icpTOF 2R是对同标称质量的离子分离要求较高的分析案例的理想选择。
Mass Resolving Power (dm/m at FWHM) | Sensitivity (cps/ppb for 238U) | All Element Analysis
| |
|---|---|---|---|
| icpTOF | 3000 | 50000 | Yes |
| icpTOF 2R | 6000 | 30000 | Yes |
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增长的离子飞行时间带来更好的质量分辨能力
- 这两款icpTOF都配备了支持Q-cell碰撞/反应技术的iCAP RQ平台（蓝色），有效降低复杂基底可能带来的干扰
- icpTOF 2R搭配的飞行时间模块（黄色）长度是icpTOF的两倍，大大提升了仪器的质量分辨能力
‘陷波’技术有效衰减等离子体和样品基底相关的离子强度
铪含量较高的’Plesovice’锆石的激光脉冲烧蚀实验信号。‘陷波’技术用来将28 -硅, 40 -氩气等离子体, 90 -锆石和 179 -铪等信号控制在10mV以下。
发表文献
icpTOF 发表文献
2018- Gundlach-Graham, A., et al. High‐Resolution, Quantitative Element Imaging of an Upper Crust, Low‐Angle Cataclasite (Zuccale Fault, Northern Apennines) by Laser Ablation ICP Time‐of‐Flight Mass Spectrometry. Geostandards and Geoanalytical Research, 2018. In Focus | DOI: 10.1111/ggr.12233
- Ohata, Masaki, and Hiroyuki Hagino. Examination on simultaneous multi-element isotope ratio measurement by inductively coupled plasma time of flight mass spectrometry. International Journal of Mass Spectrometry. 2018. In Focus | DOI:10.1016/j.ijms.2018.03.003
- Gundlach-Graham, Alexander, An Elemental Regeneration, The Analytical Scientist, 2018. URL Link
- Naasz S., et al. Multi-element analysis of single nanoparticles by ICP-MS using quadrupole and time-of-flight technologies, Journal of Analytical Atomic Spectrometry, 2018. In Focus | DOI:10.1039/C7JA00399D
- Gondikas, A., et al., Where is the nano? Analytical approaches for the detection and quantification of TiO 2 engineered nanoparticles in surface waters, Environmental Science: Nano 2018. In Focus | DOI:10.1039/c7en00952f
- Hendriks, L., et al., Analysis of Inorganic Nanoparticles by Single-Particle Inductively Coupled Plasma Time-of-Flight Mass Spectrometry, CHIMIA International Journal for Chemistry, 2018. In Focus | DOI: 10.2533/chimia.2018.221
- Hagino, Hiroyuki et. al., Application of ICP-TOFMS for Real-Time Measurement of Trace Elements in Automotive Exhaust Particulate Matters from Engine Oil Additives. Transactions of Society of Automotive Engineers of Japan, 2017. In Focus | DOI: 10.11351/jsaeronbun.48.1341
- Hendriks, L., et al., Characterization of a new ICP-TOFMS instrument with continuous and discrete introduction of solutions, Journal of Analytical Atomic Spectrometry, 2017. In Focus | DOI: 10.1039/C6JA00400H
- Burger, M., et al., Capabilities of laser ablation inductively coupled plasma time-of-flight mass spectrometry, Journal of Analytical Atomic Spectrometry, 2017. DOI: 10.1039/C7JA00236J
- Van Malderen, S., et al., Three-Dimensional reconstruction of the Tissue-Specific Multielemental Distribution within Ceriodaphnia dubia via Multimodal Registration Using Laser Ablation ICP-Mass Spectrometry and X-ray Spectroscopic Techniques, Analytical Chemistry, 2017. DOI: 10.1021/acs.analchem.7b00111
- Praetorius, A., et al., 2017, Single-particle multi-element fingerprinting (spMEF) using inductively-coupled plasma time-of-flight mass spectrometry (ICP-TOFMS) to identify engineered nanoparticles against the elevated natural background in soils, Environmental Science: Nano, 2017. In Focus |DOI: 10.1039/C6EN00455E
- Bussweiler, Y., Olga Borovinskaya, Martin Tanner., Laser Ablation and inductively coupled plasma-time-of-flight mass spectrometry-A powerful combination for high-speed multielemental imaging on the micrometer scale.” Spectroscopy, 2017. In Focus | Link
- Hao Wang et al., Simultaneous High Sensitivity Trace-Element and Isotopic Analysis of Gemstones Using Laser Ablation Inductively Coupled Plasma Time-of-Flight Mass Spectrometry, The Journal of Gemmology, 35(3), 2016.
- Wiedenbeck, M., Time-of-flight Mass Spectrometry: A New Tool for Laser Ablation Analyses, Elements Magazine, Oct. 2016. In Focus | Link
- Gundlach-Graham, Alexander, Toward faster and higher resolution LA–ICPMS imaging: on the co-evolution of LA cell design and ICPMS instrumentation, Analytical and Bioanalytical Chemistry, 2016. In Focus | DOI: 10.1007/s00216-015-9251-8
- Harlaux, M., et al., Capabilities of sequential and quasi-simultaneous LA-ICPMS for the multi-element analysis of small quantity of liquids (pl to nl): insights from fluid inclusion analysis, Journal of Analytical Atomic Spectrometry, 2015. In Focus | DOI: 10.1039/C5JA00111K
- Gundlach-Graham, A., et al., High-speed, high-resolution, multi-elemental LA-ICP-TOFMS imaging: Part I instrumentation and two-dimensional imaging of geological samples, Analytical Chemistry, 2015. In Focus | DOI:10.1021/acs.analchem.5b01196
- Burger, M., et al., High-speed, high-resolution, multi-elemental LA-ICP-TOFMS imaging: Part II. Critical evaluation of quantitative three-dimensional imaging of major, minor and trace elements in geological samples, Analytical Chemistry, 2015. In Focus | DOI: 10.1021/acs.analchem.5b01977
- Borovinskaya, O., et al., Simultaneous Mass Quantification of Nanoparticles of Different Composition in a Mixture by Microdroplet Generator-ICPTOFMS, Analytical Chemistry, 2014. In Focus | DOI: 10.1021/ac501150c
- Borovinskaya, O., et al., Diffusion- and velocity-driven spatial separation of analytes from single droplets entering an ICP off-axis, J. Anal. At. Spectrom., 2014. DOI: 10.1039/c3ja50307k
- Neubauer, Uta, Wie Forscher Nanopartikel in der Umwelt nachweisen, NZZ, 2013
- Borovinskaya, O., et al., A prototype of a new inductively coupled plasma timeof-flight mass spectrometer providing temporally resolved, multi-element detection of short signals generated by single particles and droplets, J. Anal. At. Spectrom., 2013. DOI: 10.1039/C2JA30227F
- Tanner, Martin and D. Günther, A new ICP–TOFMS. Measurement and readout of mass spectra with 30 µs time resolution, applied to in-torch LA–ICP–MS, Anal Bioanal Chem, 2008. DOI: 10.1007/s00216-008-1869-3
资源
Application Notes
- PDF - A Study of In Vivo HgSe Nanoparticle Formation with Multi-Element Single Particle ICP-TOFMS
- PDF - High Speed, High Resolution, Multi-Element Imaging of Plant Root Cross Sections to Highlight Nutrient Transport Pathways: App Note
- PDF - Quantifying the Multi-Element Composition of Single Steel Nanoparticles with the icpTOF: Application Note
- PDF - High-Speed Elemental Imaging of Cisplatin-Perfused Tissue with Laser Ablation-icpTOF: Application Note
- PDF - Fast Multi-Element LA-icpTOF Mapping of Gold Grains: Application Note
- PDF - Fast, High-Resolution Imaging of Sphalerite with the icpTOF: Application Note
- PDF - Multi-Element Detection of Single Nanoparticles with icpTOF: Application Note
- PDF - Laser Ablation with the icpTOF: Application Note
Conference Presentations
- PDF - The icpTOF as a Versatile Tool for Elemental Analysis of Single Particles and for Fast Laser Ablation Imaging: Poster APWC 2017
- High-Resolution, All-Element Imaging of a Garnet Grain with the icpTOF
- PDF - 3D Tissue Compositional Profiling with the icpTOF: Analytical Chemistry Publication and EWCPS 2017 Poster
- PDF - LA icpTOF – A Reliable Tool for Rapid Elemental Imaging of Carbonates: Poster EWCPS 2017
- PDF - SP-ICP-MS Analysis of Complex Nanoparticles in Liquids and Air: Poster ICCEEN 2016
- PDF - High-Speed, Multi-Element Imaging using Fast Laser Ablation Sampling Systems with the icpTOF: Poster EWLA 2016
- PDF - Characterizing Fe-Rich Nanoparticles: Poster ASMS 2016
- PDF - Analysis of Nanoparticles with the icpTOF: Poster WCPS 2016
Customer Research
- High-Resolution Depth Profile by fs-LA – Inductively Coupled Plasma – Mass Spectrometry
- Elemental Imaging with the icpTOF Furthers Understanding of Fault Formation
- Performance Comparison of Multi-Element Isotope Ratio Measurements with ICP-TOFMS
- Analysis of Inorganic Nanoparticles in Complex Matrices
- Characterizing the Performance of the icpTOF for Continuous Solutions and Single Microdroplets
- Single-Particle Multi-Element Fingerprinting of Engineered Nanoparticles in Soils with icpTOF
- Toward Faster and Higher Resolution LA–ICPMS Imaging
- The Advantages of TOF for ICP-MS Analysis of Fluid Inclusions
- High-Speed, Multi-Elemental Imaging for Geological Samples with LA-ICP-TOFMS
Knowledge
- 为什么飞行时间质谱（TOFMS）是相对于四级杆质谱（QMS）更理想的检测器？
- What is Single Particle ICP-MS?
- What is Laser Ablation ICP-MS Imaging?
TOFWERK Publications
- Real-Time Measurement of Trace Elements in Automotive Exhaust
- Advantages of TOFMS for Single Nanoparticle ICP-MS
- Detection and Quantification of Titanium Dioxide Engineered Nanoparticles in Surface Waters
- Perspective Article on Multielemental Imaging with Laser Ablation ICP–TOFMS in May Issue of Spectroscopy
- Quantification of Metallic Nanoparticles with ICP-TOFMS
Webinars
- PDF - 网络讲堂: Maximum Sensitivity for Particles, Cells, and Bioimaging with the icpTOF S2
- PDF - icpTOF Webinar Series: Multi-Element Laser Ablation Imaging and Spot Analysis - 观看视频
- PDF - icpTOF Webinar Series: Multi-Element, Single-Particle Analysis - 观看视频
- PDF - Webinar: Fundamentals and Applications of the icpTOF - 观看视频
基础知识
icpTOF的背景知识
