icpTOF是单颗粒多元素分析和快速激光蚀刻成像的理想选择

icpTOF R, icpTOF 2R, 和icpTOF S2 型号规格一览

icpTOF R， icpTOF 2R和icpTOF S2 在Thermo Scientific公司的 iCAP RQ平台（包含离子源和真空接口）上耦合了TOFWERK高性能飞行时间质谱分析仪。这三种型号性能各有千秋，适用于您的多种应用需求。icpTOF 2R搭配一款更长的飞行时间质谱模块，提供高达6000的质量分辨率，是对同标称质量的离子分离要求较高的分析案例的理想选择。S2型号的超高灵敏度可以提升生物样品成像的空间分辨率，同时也可以在分析细小颗粒物时有更好的信噪比。

下载完整的icpTOF规格表格

icpTOF Hardware Design

增长的离子飞行时间带来更好的质量分辨能力

• 这两款icpTOF都配备了支持Q-cell碰撞/反应技术的iCAP RQ平台（蓝色），有效降低复杂基底可能带来的干扰
• icpTOF 2R搭配的飞行时间模块（黄色）长度是icpTOF的两倍，大大提升了仪器的质量分辨能力

‘陷波’技术有效衰减等离子体和样品基底相关的离子强度

铪含量较高的’Plesovice’锆石的激光脉冲烧蚀实验信号。‘陷波’技术用来将28 -硅, 40 -氩气等离子体, 90 -锆石和 179 -铪等信号控制在10mV以下。

icpTOF 发表文献

2022

1. Chronakis, M.; von der Au, M.; Meermann, B. Single Cell-Asymmetrical Flow Field-Flow Fractionation/ICP-Time of Flight-Mass Spectrometry (sc-AF4/ICP-ToF-MS): An efficient alternative for the cleaning and multielemental analysis of individual cells.  J.Anal.At.Spectrom, 2022. DOI:10.1039/D2JA00264G
2. Olbrich et al. Beyond corrosion: development of a single cell-ICP-ToF-MS method to uncover the process of microbiologically influenced corrosion.  Metallomics, 2022. DOI:10.1093/mtomcs/mfac083 
3. Wang et al. Laser ablation-single particle-inductively coupled plasma mass spectrometry as a sensitive tool for bioimaging of silver nanoparticles in vivo degradation. Chinese Chemical Letters, 2022. DOI: 10.1016/j.cclet.2022.03.098
4. Bland, G.; Zhang, P.; Valsami-Jones, E.; and Lowry, G.V. Application of Isotopically Labeled Engineered Nanomaterials for Detection and Quantification in Soils via Single-Particle Inductively Coupled Plasma Time-of-Flight Mass Spectrometry. Environ. Sci. Technol., 2022. DOI: 10.1021/acs.est.2c03737
5. Taskula, S.; Stetten, L.; von der Kammer, F.; Hofmann, T. Platinum Nanoparticle Extraction, Quantification, and Characterization in Sediments by Single-Particle Inductively Coupled Plasma Time-of-Flight Mass Spectrometry. Nanomaterials, 2022. DOI: 10.3390/nano12193307
6. Tou et al. Multi-method approach for analysis of road dust particles: elemental ratios, SP-ICP-TOF-MS, and TEM. Environ. Sci.: Nano, 2022. DOI: 10.1039/D2EN00409G
7. Becker, P.; Koch, J.; Günther, D. Impact of ablation cell design in LA-ICP-MS quantification. Journal of Analytical Atomic Spectrometry, 2022. DOI: 10.1039/D2JA00167E
8. Nakazato, M.; Asanuma, H.; Niki, S.; Iwano, H.; Hirata , T. Depth‐Profiling Determinations of Rare Earth Element Abundances and U‐Pb Ages from Zircon Crystals Using Sensitivity‐Enhanced Inductively Coupled Plasma‐Time of Flight‐Mass Spectrometry. Geostandards and Geoanalytical Research, 2022. DOI: 10.1111/ggr.12446
9. Goodman, A.; Gundlach-Graham, A.; Bevers, S.; Ranville, J. Characterization of nano-scale mineral dust aerosols in snow by single particle inductively coupled plasma mass spectrometry. Environ. Sci.: Nano, 2022. DOI: 10.1039/D2EN00277A
10. Tian et al. Simultaneous multi-element and multi-isotope detection in single-particle ICP-MS analysis: Principles and applications. TrAC Trends in Analytical Chemistry, 2022. DOI: 10.1016/j.trac.2022.116746
11. Schweikert et al. Quantification in bioimaging by LA-ICPMS – Evaluation of isotope dilution and standard addition enabled by micro-droplets. Analytica Chimica Acta, 2022. DOI: 10.1016/j.aca.2022.340200
12. Koolen et al. High-Throughput Sizing, Counting, and Elemental Analysis of Anisotropic Multimetallic Nanoparticles with Single-Particle Inductively Coupled Plasma. ACS Nano, 2022. DOI: 10.1021/acsnano.2c01840
13. Mehrabi, K.; Dengler, M.; Nilsson, I.; Baumgartner, M.; Mora, C.: Günther D.; Gundlach-Graham A. Detection of magnetic iron nanoparticles by single-particle ICP-TOFMS: case study for a magnetic filtration medical device. Anal Bioanal Chem, 2022. DOI: 10.1007/s00216-022-04234-w
14. Foster et al. Accumulation of molybdenum in major organs following repeated oral administration of bis‐choline tetrathiomolybdate in the Sprague Dawley rat. Journal of Applied Toxicology, 2022. DOI:10.1002/jat.4358
15. von der Au, M.; Faßbender, S.; Ioannis Chronakis, M.; Vogl, J.; Meermann, B. Size determination of nanoparticles by ICP-ToF-MS using isotope dilution in microdroplets, J. Anal. At. Spectrom., 2022. DOI:10.1039/D2JA00072E
16. Harycki, S.; Gundlach-Graham, A. Online microdroplet calibration for accurate nanoparticle quantification in organic matrices. Anal Bioanal Chem, 2022.  DOI:10.1007/s00216-022-04115-2
17. Montaño et al. Exploring Nanogeochemical Environments: New Insights from Single Particle ICP-TOFMS and AF4-ICPMS. ACS Earth Space Chem, 2022.  DOI: 10.1021/acsearthspacechem.1c00350 
18. Szakas, S.; Lancaster, R.; Kaegi, R.; Gundlach-Graham, A. Quantification and Classification of Engineered, Incidental, and Natural Cerium-Containing Particles by spICP-TOFMS. Environmental Science: Nano, 2022.  DOI: 10.1039/D1EN01039E    
19. Minelli et al. Versailles project on advanced materials and standards (VAMAS) interlaboratory study on measuring the number concentration of colloidal gold nanoparticles. Nanoscale, 2022, Advance Article.  DOI: 10.1039/D1NR07775A  
20. Bland et al. Distinguishing Engineered TiO2 Nanomaterials from Natural Ti Nanomaterials in Soil Using spICP-TOFMS and Machine Learning. Environ. Sci. Technol., 2022. In Focus | DOI: 10.1021/acs.est.1c02950 
21. Neff, C.; Becker, P.; Gunther, D. Parallel flow ablation cell for short signal duration in LA-ICP-TOFMS element imaging. Journal of Analytical Atomic Spectrometry, 2022. In Focus | DOI: 10.1039/D1JA00421B
22. Voloaca et al. Elemental Mapping of Human Malignant Mesothelioma Tissue Samples Using High-Speed LA−ICP−TOFMS Imaging. Analytical Chemistry, 2022.  DOI: 10.1021/acs.analchem.1c04857
23. Brünjes, R.; Schüürman, J.; von der Kammer, F.; Hofmann, T.  Rapid Analysis of Gunshot Residues with Single Particle Inductively Coupled Plasma Time-of-Flight Mass Spectrometry. Forensic Science International, 2022.  DOI: 10.1016/j.forsciint.2022.111202
24. Wang. J.; Nabi, M.; Erfani, M.;  Goharian, E.; Baalousha, M. Identification and Quantification of Anthropogenic Nanomaterials in Urban Rain and Runoff Using Single Particle-Inductively Coupled Plasma-Time of Flight-Mass Spectrometry. Environmental Science Nano, 2022.  DOI:10.1039/D1EN00850A

2021

1. Schoeberl et al. Cisplatin Uptake in Macrophage Subtypes at the Single-Cell Level by LA-ICP-TOFMS Imaging. Analytical Chemistry, 2021. DOI:10.1021/acs.analchem.1c03442
2. Qin, W.; Stärk, H.J.; Reemtsma, T. Ruthenium red: a highly efficient and versatile cell staining agent for single-cell analysis using inductively coupled plasma time-of-flight mass spectrometry. Analyst, communication, 2021.
   DOI:10.1039/D1AN01143J
3. Holbrook, T.; Gallot-Duval, D.; Reemtsma, T.; Wagner, S. Machine learning: our future spotlight into single-particle ICP-ToF-MS analysis. Journal of Analytical Atomic Spectrometry, 2021.  In Focus | DOI:10.1039/D1JA00213A
4. Nabi M,; Wang J.; Goharian E.; Baalousha, M. Temporal variation in TiO2 engineered particle concentrations in the Broad River during dry and wet weathers. Science of the Total Environment, 2021. DOI:10.1016/j.scitotenv.2021.151081
5. Holbrook, T.;  Gallot-Duval, D.; Reemtsma, T.; Wagner, S.  An investigation into LA-spICP-ToF-MS uses for in situ measurement of environmental multi-elemental nanoparticles. Journal of Analytical Atomic Spectrometry, 2021. In Focus | DOI: 10.1039/D1JA00112D
6. Xu et al. Impacts of Sediment Particle Grain Size and Mercury Speciation on Mercury Bioavailability Potential. Environ. Sci. Technol. 2021. DOI:10.1021/acs.est.1c03572
7. Förster, M.; Bussweiler, Y.; Prelevic, D.; Daczko, N.; Buhre, S.; Mertz-Kraus, R.;  Foley D. Sediment-Peridotite Reaction Controls Fore-Arc Metasomatism and Arc Magma Geochemical Signatures, Geosciences, 2021. In Focus | DOI: 10.3390/geosciences11090372
8. Schueffl et al. Albumin-targeting of an oxaliplatin-releasing platinum(IV) prodrug results in pronounced anticancer activity due to endocytotic drug uptake in vivo. Chemical Science, 2021. DOI: 10.1039/d1sc03311e
9. Mehrabi, K.; Kaegi, R.; Günther, D.; Gundlach-Graham, A. Quantification and Clustering of Inorganic Nanoplastics in Wastewater Treatment Plants acros Switzerland. Chimia, 2021. In Focus | DOI:10.2533/chimia.2021.642
10. Faßbender et al. Species-specific isotope dilution analysis of monomethylmercury in sediment using GC/ICP-ToF-MS and comparison with ICP-Q-MS and ICP-SF-MS. Analytical and Bioanalytical Chemistry, 2021. In Focus | DOI: 10.1007/s00216-021-03497-z
11. Norrfors, K.K.; Micić, V.; Borovinskaya, O.; von der Kammer, F.; Hofmann, T.; Cornelis, G. A critical evaluation of short columns forestimating the attachment efficiency ofengineered nanomaterials in  natural soils. Environmental Science: Nano, 2021. In Focus | DOI: 10.1039/d0en01089h
12. Baalousha, M.; Wang, J.; Erfani, M.; Goharian, E. Elemental fingerprints in natural nanomaterials determined using SP-ICP-TOF-MS and clustering analysis. Science of The Total Environment, 2021.  In Focus| DOI: 10.1016/j.scitotenv.2021.148426
13. Schweikert et al. Micro-droplet-based calibration for quantitative elemental bioimaging by LA-ICPMS. Analytical and Bioanalytical Chemistry, 2021.  In Focus | DOI:10.1007/s00216-021-03357-w
14. Krzemnicki, M.; Wang, H.; Büche, S. A New Type of Emerald from Afghanistan’s Panjshir Valley. The Journal of Gemmology, 2021. DOI:10.15506/JoG.2021.37.5.474
15. Mehrabi, K.; Kaegi, R.; Günther, D.; Gundlach-Graham, A. Emerging investigator series: Automated Single-Nanoparticle Quantification and Classification: A Holistic Study of Particles into and out of Wastewater Treatment Plants in Switzerland. Environ. Sci.: Nano, 2021. In Focus | DOI:10.1039/D0EN01066A
16. Gundlach-Graham, A. Multiplexed and multi-metal single-particle characterization with ICP-TOFMS. Chapter in Comprehensive Analytical Chemistry, 2021. In Focus | DOI: 10.1016/bs.coac.2021.01.008
17. Meili-Borovinskaya et al. Analysis of Complex Particle Mixtures by Asymmetrical Flow Field-Flow Fractionation Coupled to Inductively Coupled Plasma Time-of-Flight Mass Spectrometry. Journal of Chromatography, 2021. In Focus | DOI: 10.1016/j.chroma.2021.461981
18. Theiner, S.; Schoeberl, A.;  Schweikert, A.; Keppler, B.;  Koellensperger, G. Mass spectrometry techniques for imaging and detection of metallodrugs. Current Opinion in Chemical Biology, 2021.  In Focus | DOI:10.1016/j.cbpa.2020.12.005
19. Wang, H.; Krzemnicki, M. Multi-element analysis of minerals using laser ablation inductively couple plasma time-of-flight mass spectrometry and geochemical data visualization using t-distributed stochastic neighbor embedding: Case study on emeralds from various deposits. Journal of Analytical Atomic Spectrometry, 2021. In Focus | DOI: 10.1039/D0JA00484G
20. Jahn, L.; Bland, G.; Monroe, L.; Sullivan, R.; Meyer, M. Single-Particle Elemental Analysis of Vacuum Bag Dust Samples Collected From the International Space Station by SEM/EDX and sp-ICP-ToF-MS. Aerosol Science and Technology, 2021. In Focus | DOI: 10.1080/02786826.2021.1874610
21. Chapman et al. Chemical and physical heterogeneity within native gold: Implications for the design of gold particles studies. Mineralium Deposita, 2021. In Focus | DOI: 10.1007/s00126-020-01036-x  
22. Wernitznig et al. Plecstatin-1 induces an immunogenic cell death signature in colorectal tumour spheroids. Metallomics, 2021. In Focus | DOI: 10.1039/D0MT00227E
23. Chew, D.; Drost, K.; Marsh, J.; Petrus, J. LA-ICP-MS imaging in the geosciences and its applications to geochronology. Chemical Geology, 2021. In Focus | DOI: 10.1016/j.chemgeo.2020.119917
24. Nabi, M.; Wang, J.; Baalousha, M. Episodic surges in titanium dioxide engineered particle concentrations in surface waters following rainfall events.  Chemosphere, 2021. In Focus |  DOI: 10.1016/j.chemosphere.2020.128261

2020

1. Jahn, L. et al. Metallic and Crustal Elements in Biomass-Burning Aerosol and Ash: Prevalence, Significance, and Similarity to Soil Particles. ACS Earth Space Chem, 2020. DOI: 10.1021/acsearthspacechem.0c00191
2. Laughton, S. et al.  Methanol-based extraction protocol for insoluble and moderately water-soluble nanoparticles in plants to enable characterization by single particle ICP-MS. Analytical and Bioanalytical Chemistry, 2020. In Focus | DOI:10.1007/s00216-020-03014-8
3. Hendriks, L.; Skjolding, L. Single-Cell Analysis by Inductively Coupled Plasma–Time-of-Flight Mass Spectrometry to Quantify Algal Cell Interaction with Nanoparticles by Their Elemental Fingerprint. Spectroscopy, 2020. In Focus 
4. Theiner, S. et al.  Single-Cell Analysis by Use of ICP-MS. Journal of Analytical Atomic Spectrometry 2020.  In Focus | DOI: 10.1039/D0JA00194E
5. Gundlach-Graham, A. & Mehrabi, K. Monodisperse Microdroplets: A Tool that Advances Single-Particle ICP-MS Measurements. Journal of Analytical Atomic Spectrometry 2020.  In Focus | DOI: 10.1039/D0JA00213E
6. Thompson, J.; Danyushevsky, L.; Borovinskaya, O.; Tanner, M. Time-of-flight ICP-MS laser ablation zircon geochronology: assessment and comparison against quadrupole ICP-MS. Journal of Analytical Atomic Spectrometry 2020.  In Focus |  DOI: 10.1039/d0ja00252f
7. Neff, C. et al. Capabilities of automated LA-ICP-TOFMS imaging of geological samples. Journal of Analytical Atomic Spectrometry 2020. In Focus | DOI: 10.1039/D0JA00238K  
8. Becker, P. et al.  Forensic Float Glass Fragment Analysis Using Single-Pulse Laser Ablation Inductively Coupled Plasma Time of Flight Mass Spectrometry. Journal of Analytical Atomic Spectrometry 2020. In Focus | DOI: 10.1039/D0JA00284D
9. Bevers, S. et al.  Quantification and Characterization of Nanoparticulate Zinc in an Urban Watershed. Frontiers in Environmental Science: Biogeochemical Dynamics 2020.  DOI: 10.3389/fenvs.2020.00084
10. Rubatto, D. et al.  Identification of growth mechanisms in metamorphic garnet by high-resolution trace element mapping with LA-ICP-TOFMS. Contrib Mineral Petrol  2020. DOI: 10.1007/s00410-020-01700-5 
11. Theiner S. et al. Laser ablation-ICP-TOFMS imaging of germ cell tumors of patients undergoing platinum-based chemotherapy. Metallomics 2020. In Focus | DOI: 10.1039/D0MT00080A
12. von der Au, M. et al. Single cell-inductively coupled plasma-time of flight-mass spectrometry approach for ecotoxicological testing. Algal Research 2020. In Focus | DOI:10.1016/j.algal.2020.101964
13. Bussweiler, Y. et al. Trace element mapping of high-pressure, high-temperature experimental samples with laser ablation ICP time-of-flight mass spectrometry–Illuminating melt-rock reactions in the lithospheric mantle. Lithos, 2020.  In Focus | DOI: 10.1016/j.lithos.2019.105282
14. Van Malderen, S., Van Acker, T., Vanhaecke, F. Sub-µm nanosecond LA-ICP-MS imaging at pixel acquisition rates above 250 Hz via a low-dispersion setup.  Analytical Chemistry 2020. In Focus | DOI:10.1021/acs.analchem.9b05056 
15. Phyo, M.M. et al. U–Pb Dating of Zircon and Zirconolite Inclusions in Marble-Hosted Gem-Quality Ruby and Spinel from Mogok, Myanmar. Minerals 2020. In Focus | DOI: 10.3390/min10020195

2019

1. Erhardt, T.; Jensen, C.; Borovinskaya, O.; Fischer, H. Single particle characterization and total elemental concentration measurements in polar ice using CFA-icpTOF. Environmental  Science & Technology 2019. In Focus | DOI: 10.1021/acs.est.9b03886
2. Mehrabi, K.; Günther, D.; Gundlach-Graham, A. Single-Particle ICP-TOFMS with Online Microdroplet Calibration for the Simultaneous Quantification of Diverse Nanoparticles in Complex Matrices. Environmental Science: Nano 2019. DOI: 10.1039/C9EN00620F
3. Ubide, T.; Caulfield, J.; Brandt, C.; Bussweiler, Y.; Mollo, S.; Di Stefano, F.; Nazzari, M.; Scarlato, P. Deep Magma Storage revealed by Multi-Method Elemental Mapping of Clinopyroxene Megacrysts at Stromboli Volcano. Frontiers in Earth Science 2019. In Focus | DOI:10.3389/feart.2019.00239
4. Theiner, S.; Schoeberl, A.; Fischer, L.; Neumayer, S.; Hann, S.; Koellensperger, G. FI-ICP-TOFMS for quantification of biologically essential trace elements in cerebrospinal fluid-high-throughput at low sample volume. Analyst 2019.  DOI:10.1039/C9AN00039A
5. Löhr, K.; Borovinskaya, O., Tourniaire, G.; Panne, U.; Jakubowski, N. Arraying of single cells for quantitative highthroughput Laser Ablation ICP-TOF-MS. Analytical Chemistry 2019. DOI:10.1021/acs.analchem.9b00198
6. Hendriks, L.; Gundlach-Graham, A.; Günther, D. Performance of sp-ICP-TOFMS with signal distributions fitted to a compound Poisson model. Journal of Analytical Atomic Spectrometry 2019.  DOI:10.1039/C9JA00186G
7. Arakawa, A.; Jakubowski, N.; Koellensperger, G.; Theiner, S.; Schweikert, A.;  Flemig, S.; Iwahata, D.; Traub, H.; Hirata, T. Quantitative imaging of silver nanoparticles and essential elements in thin sections of fibroblast multicellular spheroids by high resolution laser ablation inductively coupled plasma time-of-flight mass spectrometry (LA-ICP-TOF-MS).  Analytical Chemistry 2019.  DOI:10.1021/acs.analchem.9b02239
8. Krebs, M.; Pearson, D.;  Fagan, A.; Bussweiler, Y.; Sarkar, C. The application of trace elements and Sr–Pb isotopes to dating and tracing ruby formation: The Aappaluttoq deposit, SW Greenland. Chemical Geology 2019.  DOI:10.1016/j.chemgeo.2019.05.035
9. Theiner, S.; Schweikert, A.; Van Malderen, S.;  Schoeberl, A.;  Neumayer, S.;  Jilma, P.;  Peyrl, A.; Koellensperger, G. Laser ablation-inductively coupled plasma time-of-flight mass spectrometry imaging of trace elements at single cell level for clinical practice. Analytical Chemistry 2019.  DOI:10.1021/acs.analchem.9b00698
10. Theiner, S.; Schoeberl, A.; Neumayer, S.; Koellensperger, G. FI-ICP-TOFMS for high-throughput and low volume multi-element analysis in environmental and biological matrices. Journal of Analytical Atomic Spectrometry 2019.  DOI:10.1039/C9JA00022D
11. Loosli, F.; Wang, J.; Rothenberg, S.;  Bizimis, M.; Winkler, C.; Borovinskaya, O.; Flamigni, L.; Baalousha, M. Sewage spills are a major source of titanium dioxide engineered (nano)-particles into the environment. Environ. Sci.: Nano 2019. In Focus | DOI: 10.1039/c8en01376d
12. Bauer, O.; Hachmöller, O.; Borovinskaya, O.; Sperling, M.; Schurek, H.;  Ciarimboli, G.; Karst, U. LA-ICP-ToFMS for rapid, all-elemental and quantitative bioimaging, isotopic analysis and the investigation of plasma processes”, Journal of Analytical Atomic Spectrometry 2019. In Focus | DOI: 10.1039/C8JA00288F
13. Hendriks, L.; Ramkorun-Schmidt, B.; Gundlach-Graham, A.; Koch, J.; Grass, R. N.; Jakubowski, N.; Gunther, D. Single-Particle ICP-MS with Online Microdroplet Calibration: Toward Matrix Independent Nanoparticle Sizing. Journal of Analytical Atomic Spectrometry 2019. In Focus | DOI: 10.1039/C8JA00397A
14. Burgay, F.; Erhardt, T.; Lunga, D. D.; Jensen, C. M.; Spolaor, A.; Vallelonga, P.; Fischer, H.; Barbante, C.;  Fe2+ in ice cores as a new potential proxy to detect past volcanic eruptions. Science of The Total Environment 2019. In Focus | DOI: 10.1016/j.scitotenv.2018.11.075
15. Burger, M.; Hendriks, L.; Kaeslin, J.; Gundlach-Graham, A.; Hattendorf, B.; Günther, D. Characterization of inductively coupled plasma time-of-flight mass spectrometry in combination with collision/reaction cell technology–insights from highly time-resolved measurements. Journal of Analytical Atomic Spectrometry 2019. In Focus | DOI: 10.1039/C8JA00275D

2018

1. Gundlach-Graham, A., et al. High‐Resolution, Quantitative Element Imaging of an Upper Crust, Low‐Angle Cataclasite (Zuccale Fault, Northern Apennines) by Laser Ablation ICP Time‐of‐Flight Mass Spectrometry. Geostandards and Geoanalytical Research, 2018. In Focus | DOI: 10.1111/ggr.12233
2. Ohata, Masaki, and Hiroyuki Hagino. Examination on simultaneous multi-element isotope ratio measurement by inductively coupled plasma time of flight mass spectrometry. International Journal of Mass Spectrometry. 2018. In Focus | DOI:10.1016/j.ijms.2018.03.003
3. Gundlach-Graham, Alexander, An Elemental Regeneration, The Analytical Scientist, 2018. URL Link
4. Naasz S., et al. Multi-element analysis of single nanoparticles by ICP-MS using quadrupole and time-of-flight technologies, Journal of Analytical Atomic Spectrometry, 2018. In Focus | DOI:10.1039/C7JA00399D
5. Gondikas, A., et al., Where is the nano? Analytical approaches for the detection and quantification of TiO 2 engineered nanoparticles in surface waters, Environmental Science: Nano 2018.  In Focus | DOI:10.1039/c7en00952f
6. Hendriks, L., et al., Analysis of Inorganic Nanoparticles by Single-Particle Inductively Coupled Plasma Time-of-Flight Mass Spectrometry, CHIMIA International Journal for Chemistry, 2018. In Focus | DOI: 10.2533/chimia.2018.221

2017

1. Hagino, Hiroyuki et. al., Application of ICP-TOFMS for Real-Time Measurement of Trace Elements in Automotive Exhaust Particulate Matters from Engine Oil Additives. Transactions of Society of Automotive Engineers of Japan, 2017. In Focus | DOI: 10.11351/jsaeronbun.48.1341 
2. Hendriks, L., et al., Characterization of a new ICP-TOFMS instrument with continuous and discrete introduction of solutions, Journal of Analytical Atomic Spectrometry, 2017.  In Focus | DOI: 10.1039/C6JA00400H
3. Burger, M., et al., Capabilities of laser ablation inductively coupled plasma time-of-flight mass spectrometry, Journal of Analytical Atomic Spectrometry, 2017. DOI: 10.1039/C7JA00236J
4. Van Malderen, S., et al., Three-Dimensional reconstruction of the Tissue-Specific Multielemental Distribution within Ceriodaphnia dubia via Multimodal Registration Using Laser Ablation ICP-Mass Spectrometry and X-ray Spectroscopic Techniques, Analytical Chemistry, 2017. DOI: 10.1021/acs.analchem.7b00111
5. Praetorius, A., et al., 2017, Single-particle multi-element fingerprinting (spMEF) using inductively-coupled plasma time-of-flight mass spectrometry (ICP-TOFMS) to identify engineered nanoparticles against the elevated natural background in soils, Environmental Science: Nano, 2017.  In Focus |DOI: 10.1039/C6EN00455E
6. Bussweiler, Y., Olga Borovinskaya, Martin Tanner., Laser Ablation and inductively coupled plasma-time-of-flight mass spectrometry-A powerful combination for high-speed multielemental imaging on the micrometer scale.” Spectroscopy, 2017. In Focus | Link

2016

1. Hao Wang et al., Simultaneous High Sensitivity Trace-Element and Isotopic Analysis of Gemstones Using Laser Ablation Inductively Coupled Plasma Time-of-Flight Mass Spectrometry, The Journal of Gemmology, 35(3), 2016.
2. Wiedenbeck, M., Time-of-flight Mass Spectrometry: A New Tool for Laser Ablation Analyses, Elements Magazine, Oct. 2016. In Focus | Link
3. Gundlach-Graham, Alexander, Toward faster and higher resolution LA–ICPMS imaging: on the co-evolution of LA cell design and ICPMS instrumentation, Analytical and Bioanalytical Chemistry, 2016.  In Focus | DOI: 10.1007/s00216-015-9251-8

2015

1. Harlaux, M., et al., Capabilities of sequential and quasi-simultaneous LA-ICPMS for the multi-element analysis of small quantity of liquids (pl to nl): insights from fluid inclusion analysis, Journal of Analytical Atomic Spectrometry, 2015.  In Focus | DOI: 10.1039/C5JA00111K
2. Gundlach-Graham, A., et al., High-speed, high-resolution, multi-elemental LA-ICP-TOFMS imaging: Part I instrumentation and two-dimensional imaging of geological samples, Analytical Chemistry, 2015. In Focus | DOI:10.1021/acs.analchem.5b01196
3. Burger, M., et al., High-speed, high-resolution, multi-elemental LA-ICP-TOFMS imaging: Part II. Critical evaluation of quantitative three-dimensional imaging of major, minor and trace elements in geological samples,  Analytical Chemistry, 2015. In Focus | DOI: 10.1021/acs.analchem.5b01977

2014

1. Borovinskaya, O., et al., Simultaneous Mass Quantification of Nanoparticles of Different Composition in a Mixture by Microdroplet Generator-ICPTOFMS,  Analytical Chemistry, 2014.  In Focus | DOI: 10.1021/ac501150c
2. Borovinskaya, O., et al., Diffusion- and velocity-driven spatial separation of analytes from single droplets entering an ICP off-axis,  J. Anal. At. Spectrom., 2014. DOI: 10.1039/c3ja50307k

2013

1. Neubauer, Uta, Wie Forscher Nanopartikel in der Umwelt nachweisen, NZZ, 2013
2. Borovinskaya, O., et al., A prototype of a new inductively coupled plasma timeof-flight mass spectrometer providing temporally resolved, multi-element detection of short signals generated by single particles and droplets, J. Anal. At. Spectrom., 2013. DOI: 10.1039/C2JA30227F

2008

1. Tanner, Martin and D. Günther, A new ICP–TOFMS. Measurement and readout of mass spectra with 30 µs time resolution, applied to in-torch LA–ICP–MS,  Anal Bioanal Chem, 2008. DOI: 10.1007/s00216-008-1869-3

• Imaging the Distribution of Elements in Antarctic Ice Cores with LA-ICP-TOFMS PDF
• Single Cell ICP-MS Analysis with the icpTOF Provides New Insights into Cell Ionomics PDF
• icpTOF质谱单颗粒多元素分析案例：活体内汞硒共生纳米颗粒物生成机理研究 PDF
• High Speed, High Resolution, Multi-Element Imaging of Plant Root Cross Sections to Highlight Nutrient Transport Pathways: App Note PDF
• Quantifying the Multi-Element Composition of Single Steel Nanoparticles with the icpTOF: Application Note PDF
• High-Speed Elemental Imaging of Cisplatin-Perfused Tissue with Laser Ablation-icpTOF: Application Note PDF
• Fast Multi-Element LA-icpTOF Mapping of Gold Grains: Application Note PDF
• Fast, High-Resolution Imaging of Sphalerite with the icpTOF: Application Note PDF
• Multi-Element Detection of Single Nanoparticles with icpTOF: Application Note PDF
• Laser Ablation with the icpTOF: Application Note PDF

• The icpTOF as a Versatile Tool for Elemental Analysis of Single Particles and for Fast Laser Ablation Imaging: Poster APWC 2017 PDF
• High-Resolution, All-Element Imaging of a Garnet Grain with the icpTOF
• 3D Tissue Compositional Profiling with the icpTOF: Analytical Chemistry Publication and EWCPS 2017 Poster PDF
• LA icpTOF – A Reliable Tool for Rapid Elemental Imaging of Carbonates: Poster EWCPS 2017 PDF
• SP-ICP-MS Analysis of Complex Nanoparticles in Liquids and Air: Poster ICCEEN 2016 PDF
• High-Speed, Multi-Element Imaging using Fast Laser Ablation Sampling Systems with the icpTOF: Poster EWLA 2016 PDF
• Characterizing Fe-Rich Nanoparticles: Poster ASMS 2016 PDF
• Analysis of Nanoparticles with the icpTOF: Poster WCPS 2016 PDF

• Combining Laser Ablation with Single Particle ICP-TOFMS for the Study of Multi-Element Particles in Environmental Systems
• Online Microdroplet Calibration with the icpTOF Enables High-Throughput Nanoparticle Studies
• fs-LA-icpTOF 飞秒激光剥蚀ICP质谱仪助 力高分辨率深度剖面分析
• icpTOF质谱元素成像分析洞察岩石样品内Fault Formation机理
• icpTOF全谱检测多种元素及其同位素分布及比例
• Analysis of Inorganic Nanoparticles in Complex Matrices
• Characterizing the Performance of the icpTOF for Continuous Solutions and Single Microdroplets
• Single-Particle Multi-Element Fingerprinting of Engineered Nanoparticles in Soils with icpTOF
• Toward Faster and Higher Resolution LA–ICPMS Imaging
• The Advantages of TOF for ICP-MS Analysis of Fluid Inclusions
• High-Speed, Multi-Elemental Imaging for Geological Samples with LA-ICP-TOFMS

• 为什么飞行时间质谱（TOFMS）是相对于四级杆质谱（QMS）更理想的检测器？
• 粒粒皆信息：什么是单颗粒物ICP-MS质谱分析法?
• 步步生花：什么是激光剥蚀ICP-MS质谱成像？

• 机动车尾气中颗粒物伴生痕量元素组分实时在线分析
• 为什么TOF飞行时间质谱是单颗粒icp质谱仪的最佳搭配，没有唯一？
• Detection and Quantification of Titanium Dioxide Engineered Nanoparticles in Surface Waters
• Perspective Article on Multielemental Imaging with Laser Ablation ICP–TOFMS in May Issue of Spectroscopy
• Quantification of Metallic Nanoparticles with ICP-TOFMS

• 网络讲堂: Maximum Sensitivity for Particles, Cells, and Bioimaging with the icpTOF S2 PDF
• icpTOF Webinar Series: Multi-Element Laser Ablation Imaging and Spot Analysis 观看视频 PDF
• icpTOF Webinar Series: Multi-Element, Single-Particle Analysis 观看视频 PDF
• Webinar: Fundamentals and Applications of the icpTOF 观看视频 PDF

icpTOF的背景知识

为什么飞行时间质谱（TOFMS）是相对于四级杆质谱（QMS）更理想的检测器？

您是否想了解飞行时间质谱仪（TOFMS）和四极杆质

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粒粒皆信息：什么是单颗粒物ICP-MS质谱分析法?

在使用电感耦合等离子质谱法（ICP-MS）进行分析

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步步生花：什么是激光剥蚀ICP-MS质谱成像？

激光剥蚀成像是一种相对较新的分析技术，可以在二维乃

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