icpTOF<\/a> 2R were used for\u00a0high-throughput\u00a0LA-ICP-TOFMS enabling multi-elemental imaging at a rate of 200 pixels per second.\u00a0Importantly, selective ablation of the gelatin micro-droplets\u00a0needs to be achieved\u00a0by selecting a\u00a0laser\u00a0energy\u00a0density below the ablation threshold of\u00a0the\u00a0glass and above the\u00a0thresholds\u00a0of gelatin and the samples.\u00a0<\/p>\n\n\n\nAnalytical figures of merit of this new calibration approach, including limits of detection, precision, and accuracy, were assessed for platinum and other elements with biological key functions, such as phosphorus, copper, and zinc. The applicability of the technique was demonstrated on tumor tissue samples containing metal-based anticancer drugs but can certainly be extended to a range of other bioimaging applications. <\/p>\n\n\n\n
*Note by TOFWERK <\/p>","protected":false},"excerpt":{"rendered":"
Micro-Droplet-Based Calibration for Quantitative Elemental Bioimaging by LA-ICPMS Schweikert et al.Analytical and Bioanalytical Chemistry, 2021DOI:10.1007\/s00216-021-03357-w In this work, researchers from the University of Vienna present a novel\u00a0\u2013\u00a0potentially groundbreaking\u00a0\u2013\u00a0standardization technique for quantitative elemental bioimaging by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). Gelatin-based micro-droplet standards\u00a0(not to be confused with liquid microdroplets\u00a0used\u00a0for single-particle\/cell standardization*)\u00a0were produced by micro-spotting\u00a0of\u00a0exact standard … \u9605\u8bfb\u66f4\u591a<\/a><\/p>","protected":false},"author":3,"featured_media":24834,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[122],"tags":[],"product_notes":[103],"class_list":["post-24830","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-customer-research","product_notes-icptof"],"acf":[],"yoast_head":"\nNovel Standardization Technique for Quantitative Bioimaging Developed with the icpTOF - TOFWERK<\/title>\n<meta name=\"description\" content=\"In this work, researchers from the University of Vienna present a novel \u2013 potentially groundbreaking \u2013 standardization technique for quantitative elemental bioimaging by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS).\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.tofwerk.com\/zh\/icptof-quantitative-bioimaging\/\" \/>\n<meta property=\"og:locale\" content=\"zh_CN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Novel Standardization Technique for Quantitative Bioimaging Developed with the icpTOF - 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