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TOFWERK Celebrates Over 50 icpTOF Publications

TOFWERK icpTOF S2 Webinar

The icpTOF user community has hit the milestone of 50 peer-reviewed publications! As of October 2020, there are 54 publications that describe scientific work done with the icpTOF across a variety of applications. A total of 13 papers were published or accepted this year alone, following 15 in 2019. According to Google Scholar, these papers have 850 citations.

icpTOF Publications by Year

When divided into different sample introduction techniques, most publications involve laser ablation sampling. However, single-particle and single-cell studies follow close behind and are increasing quickly. Sample introduction techniques labeled as “other” include flow-injection, gas exchange device, and liquid (e.g. for isotope dilution MS).

icpTOF publications by method

The publications address a wide range of applications including airborne particulate matter, nanoparticles in the environment, elemental analysis and mapping of minerals and rocks, geochronology (dating of minerals), elemental imaging of biological and clinical samples, and forensic studies (e.g., float glass and gunshot residue analysis), to name just a few. We are very happy to have such a diverse and productive customer base!

Below, we list all of the publications by year. You can browse the various icpTOF applications from the bottom of the product page.

Full List of icpTOF Publications


  1. Nabi, M.; Wang, J.; Baalousha, M. Episodic surges in titanium dioxide engineered particle concentrations in surface waters following rainfall events.  Chemosphere2021.  DOI: 10.1016/j.chemosphere.2020.128261


  1. Theiner, S. et al.  Single-Cell Analysis by Use of ICP-MS. Journal of Analytical Atomic Spectrometry 2020.  In Focus | DOI: 10.1039/D0JA00194E
  2. Gundlach-Graham, A. & Mehrabi, K. Monodisperse Microdroplets: A Tool that Advances Single-Particle ICP-MS Measurements. Journal of Analytical Atomic Spectrometry 2020.  In Focus | DOI: 10.1039/D0JA00213E
  3. Thompson, J.; Danyushevsky, L.; Borovinskaya, O.; Tanner, M. Time-of-flight ICP-MS laser ablation zircon geochronology: assessment and comparison against quadrupole ICP-MS. Journal of Analytical Atomic Spectrometry 2020.  In Focus |  DOI: 10.1039/d0ja00252f
  4. Neff, C. et al. Capabilities of automated LA-ICP-TOFMS imaging of geological samples. Journal of Analytical Atomic Spectrometry 2020In Focus | DOI: 10.1039/D0JA00238K  
  5. Becker, P. et al.  Forensic Float Glass Fragment Analysis Using Single-Pulse Laser Ablation Inductively Coupled Plasma Time of Flight Mass Spectrometry. Journal of Analytical Atomic Spectrometry 2020In Focus | DOI: 10.1039/D0JA00284D
  6. Bevers, S. et al.  Quantification and Characterization of Nanoparticulate Zinc in an Urban Watershed. Frontiers in Environmental Science: Biogeochemical Dynamics 2020.  DOI: 10.3389/fenvs.2020.00084
  7. Rubatto, D. et al.  Identification of growth mechanisms in metamorphic garnet by high-resolution trace element mapping with LA-ICP-TOFMS. Contrib Mineral Petrol  2020DOI: 10.1007/s00410-020-01700-5 
  8. Theiner S. et al. Laser ablation-ICP-TOFMS imaging of germ cell tumors of patients undergoing platinum-based chemotherapy. Metallomics 2020In Focus |DOI: 10.1039/D0MT00080A
  9. von der Au, M. et al. Single cell-inductively coupled plasma-time of flight-mass spectrometry approach for ecotoxicological testing. Algal Research 2020In Focus | DOI:10.1016/j.algal.2020.101964
  10. Bussweiler, Y. et al. Trace element mapping of high-pressure, high-temperature experimental samples with laser ablation ICP time-of-flight mass spectrometry–Illuminating melt-rock reactions in the lithospheric mantle. Lithos2020.  In Focus | DOI: 10.1016/j.lithos.2019.105282
  11. Van Malderen, S., Van Acker, T., Vanhaecke, F. Sub-µm nanosecond LA-ICP-MS imaging at pixel acquisition rates above 250 Hz via a low-dispersion setup.  Analytical Chemistry 2020In Focus | DOI:10.1021/acs.analchem.9b05056 
  12. Phyo, M.M. et al. U–Pb Dating of Zircon and Zirconolite Inclusions in Marble-Hosted Gem-Quality Ruby and Spinel from Mogok, Myanmar. Minerals 2020In Focus | DOI: 10.3390/min10020195


  1. Erhardt, T.; Jensen, C.; Borovinskaya, O.; Fischer, H. Single particle characterization and total elemental concentration measurements in polar ice using CFA-icpTOF. Environmental  Science & Technology 2019In Focus | DOI: 10.1021/acs.est.9b03886
  2. Mehrabi, K.; Günther, D.; Gundlach-Graham, A. Single-Particle ICP-TOFMS with Online Microdroplet Calibration for the Simultaneous Quantification of Diverse Nanoparticles in Complex Matrices. Environmental Science: Nano 2019DOI: 10.1039/C9EN00620F
  3. Ubide, T.; Caulfield, J.; Brandt, C.; Bussweiler, Y.; Mollo, S.; Di Stefano, F.; Nazzari, M.; Scarlato, P. Deep Magma Storage revealed by Multi-Method Elemental Mapping of Clinopyroxene Megacrysts at Stromboli Volcano. Frontiers in Earth Science 2019In Focus | DOI:10.3389/feart.2019.00239
  4. Theiner, S.; Schoeberl, A.; Fischer, L.; Neumayer, S.; Hann, S.; Koellensperger, G. FI-ICP-TOFMS for quantification of biologically essential trace elements in cerebrospinal fluid-high-throughput at low sample volume. Analyst 2019.  DOI:10.1039/C9AN00039A
  5. Löhr, K.; Borovinskaya, O., Tourniaire, G.; Panne, U.; Jakubowski, N. Arraying of single cells for quantitative highthroughput Laser Ablation ICP-TOF-MS. Analytical Chemistry 2019DOI:10.1021/acs.analchem.9b00198
  6. Hendriks, L.; Gundlach-Graham, A.; Günther, D. Performance of sp-ICP-TOFMS with signal distributions fitted to a compound Poisson model. Journal of Analytical Atomic Spectrometry 2019.  DOI:10.1039/C9JA00186G
  7. Arakawa, A.; Jakubowski, N.; Koellensperger, G.; Theiner, S.; Schweikert, A.;  Flemig, S.; Iwahata, D.; Traub, H.; Hirata, T. Quantitative imaging of silver nanoparticles and essential elements in thin sections of fibroblast multicellular spheroids by high resolution laser ablation inductively coupled plasma time-of-flight mass spectrometry (LA-ICP-TOF-MS).  Analytical Chemistry 2019.  DOI:10.1021/acs.analchem.9b02239
  8. Krebs, M.; Pearson, D.;  Fagan, A.; Bussweiler, Y.; Sarkar, C. The application of trace elements and Sr–Pb isotopes to dating and tracing ruby formation: The Aappaluttoq deposit, SW Greenland. Chemical Geology 2019.  DOI:10.1016/j.chemgeo.2019.05.035
  9. Theiner, S.; Schweikert, A.; Van Malderen, S.;  Schoeberl, A.;  Neumayer, S.;  Jilma, P.;  Peyrl, A.; Koellensperger, G. Laser ablation-inductively coupled plasma time-of-flight mass spectrometry imaging of trace elements at single cell level for clinical practice. Analytical Chemistry 2019.  DOI:10.1021/acs.analchem.9b00698
  10. Theiner, S.; Schoeberl, A.; Neumayer, S.; Koellensperger, G. FI-ICP-TOFMS for high-throughput and low volume multi-element analysis in environmental and biological matrices. Journal of Analytical Atomic Spectrometry 2019.  DOI:10.1039/C9JA00022D
  11. Loosli, F.; Wang, J.; Rothenberg, S.;  Bizimis, M.; Winkler, C.; Borovinskaya, O.; Flamigni, L.; Baalousha, M. Sewage spills are a major source of titanium dioxide engineered (nano)-particles into the environment. Environ. Sci.: Nano 2019In Focus | DOI: 10.1039/c8en01376d
  12. Bauer, O.; Hachmöller, O.; Borovinskaya, O.; Sperling, M.; Schurek, H.;  Ciarimboli, G.; Karst, U. LA-ICP-ToFMS for rapid, all-elemental and quantitative bioimaging, isotopic analysis and the investigation of plasma processes”, Journal of Analytical Atomic Spectrometry 2019In Focus | DOI: 10.1039/C8JA00288F
  13. Hendriks, L.; Ramkorun-Schmidt, B.; Gundlach-Graham, A.; Koch, J.; Grass, R. N.; Jakubowski, N.; Gunther, D. Single-Particle ICP-MS with Online Microdroplet Calibration: Toward Matrix Independent Nanoparticle Sizing. Journal of Analytical Atomic Spectrometry 2019In Focus | DOI: 10.1039/C8JA00397A
  14. Burgay, F.; Erhardt, T.; Lunga, D. D.; Jensen, C. M.; Spolaor, A.; Vallelonga, P.; Fischer, H.; Barbante, C.;  Fe2+ in ice cores as a new potential proxy to detect past volcanic eruptions. Science of The Total Environment 2019. DOI: 10.1016/j.scitotenv.2018.11.075
  15. Burger, M.; Hendriks, L.; Kaeslin, J.; Gundlach-Graham, A.; Hattendorf, B.; Günther, D. Characterization of inductively coupled plasma time-of-flight mass spectrometry in combination with collision/reaction cell technology–insights from highly time-resolved measurements. Journal of Analytical Atomic Spectrometry 2019In Focus | DOI: 10.1039/C8JA00275D


  1. Hegetschweiler, A.; Borovinskaya, O.; Staudt, T.; Kraus, T. Single particle mass spectrometry of titanium and niobium carbonitride precipitates in steels. Analytical Chemistry 2018In Focus | DOI:10.1021/acs.analchem.8b04012
  2. Gundlach-Graham, A.; Hendriks, L.; Mehrabi, K.; Günther, D.  Monte Carlo Simulation of Low-Count Signals in Time-of-Flight Mass Spectrometry and its Application to Single-Particle Detection. Analytical Chemistry 2018DOI: 10.1021/acs.analchem.8b01551
  3. Ronzani, A.; Pointurier, F.; Rittner, M.; Borovinskaya, O.; Tanner, M.; Hubert, A.; Humbert, A.C.; Aupiais, J.; Dacheux, N. Capabilities of Laser Ablation – ICP-TOF-MS Coupling for Isotopic Analysis of Individual Uranium Micrometric Particles. Journal of Analytical Atomic Spectrometry 2018In Focus | DOI: 10.1039/C8JA00241J 
  4. Käser, D.; Hendriks, L.; Koch, J.; Günther, D. Depth Profile Analyses with Sub 100-nm Depth Resolution of a Metal Thin Film by Femtosecond – Laser Ablation – Inductively Coupled Plasma – Time-of-Flight Mass Spectrometry. Spectrochimica Acta Part B: Atomic Spectroscopy 2018In Focus | DOI:10.1016/j.sab.2018.08.002
  5. Gundlach-Graham, A.; Garofalo, P.S.; Schwarz, G.; Redi, D.; Günther, D. High‐Resolution, Quantitative Element Imaging of an Upper Crust, Low‐Angle Cataclasite (Zuccale Fault, Northern Apennines) by Laser Ablation ICP Time‐of‐Flight Mass Spectrometry. Geostandards and Geoanalytical Research 2018In Focus | DOI: 10.1111/ggr.12233
  6. Ohata, M.; Hagino, H. Examination on simultaneous multi-element isotope ratio measurement by inductively coupled plasma time of flight mass spectrometry. International Journal of Mass Spectrometry 2018In Focus | DOI:10.1016/j.ijms.2018.03.003
  7. Gundlach-Graham, A. An Elemental Regeneration. The Analytical Scientist 2018URL Link
  8. Naasz, S.; et al. Multi-element analysis of single nanoparticles by ICP-MS using quadrupole and time-of-flight technologies.  Journal of Analytical Atomic Spectrometry 2018In Focus | DOI:10.1039/C7JA00399D
  9. Gondikas, A.; et al. Where is the nano? Analytical approaches for the detection and quantification of TiO 2 engineered nanoparticles in surface waters. Environmental Science: Nano 2018.  In Focus | DOI:10.1039/c7en00952f
  10. Hendriks, L.; Gundlach-Graham, A.; Günther, D. Analysis of Inorganic Nanoparticles by Single-Particle Inductively Coupled Plasma Time-of-Flight Mass Spectrometry. CHIMIA International Journal for Chemistry 2018In Focus | DOI: 10.2533/chimia.2018.221


  1. Hagino, H.; Tonegawa, Y.; Tanner, M.; Borovinskaya, O.; Hikita, T.; Shimono, A.; Application of ICP-TOFMS for Real-Time Measurement of Trace Elements in Automotive Exhaust Particulate Matters from Engine Oil Additives. Transactions of Society of Automotive Engineers of Japan 2017In Focus | DOI: 10.11351/jsaeronbun.48.1341 
  2. Hendriks, L.; et al. Characterization of a new ICP-TOFMS instrument with continuous and discrete introduction of solutions, Journal of Analytical Atomic Spectrometry 2017.  In Focus | DOI: 10.1039/C6JA00400H
  3. Burger, M.; et al. Capabilities of laser ablation inductively coupled plasma time-of-flight mass spectrometry. Journal of Analytical Atomic Spectrometry 2017DOI: 10.1039/C7JA00236J
  4. Van Malderen, S.; et al. Three-Dimensional reconstruction of the Tissue-Specific Multielemental Distribution within Ceriodaphnia dubia via Multimodal Registration Using Laser Ablation ICP-Mass Spectrometry and X-ray Spectroscopic Techniques. Analytical Chemistry 2017DOI: 10.1021/acs.analchem.7b00111
  5. Praetorius, A.; et al. Single-particle multi-element fingerprinting (spMEF) using inductively-coupled plasma time-of-flight mass spectrometry (ICP-TOFMS) to identify engineered nanoparticles against the elevated natural background in soils. Environmental Science: Nano 2017.  In Focus |DOI: 10.1039/C6EN00455E
  6. Bussweiler, Y.; Borovinskaya, O.; Tanner, M. Laser Ablation and inductively coupled plasma-time-of-flight mass spectrometry-A powerful combination for high-speed multielemental imaging on the micrometer scale. Spectroscopy 2017In Focus Link


  1. Wang, H.; et al. Simultaneous High Sensitivity Trace-Element and Isotopic Analysis of Gemstones Using Laser Ablation Inductively Coupled Plasma Time-of-Flight Mass Spectrometry. The Journal of Gemmology 2016.
  2. Wiedenbeck, M. Time-of-flight Mass Spectrometry: A New Tool for Laser Ablation Analyses. Elements Magazine 2016In Focus | Link
  3. Gundlach-Graham, A. Toward faster and higher resolution LA–ICPMS imaging: on the co-evolution of LA cell design and ICPMS instrumentation.  Analytical and Bioanalytical Chemistry 2016.  In Focus | DOI: 10.1007/s00216-015-9251-8


  1. Harlaux, M.; et al. Capabilities of sequential and quasi-simultaneous LA-ICPMS for the multi-element analysis of small quantity of liquids (pl to nl): insights from fluid inclusion analysis.  Journal of Analytical Atomic Spectrometry 2015.  In Focus | DOI: 10.1039/C5JA00111K
  2. Gundlach-Graham, A.; et al. High-speed, high-resolution, multi-elemental LA-ICP-TOFMS imaging: Part I instrumentation and two-dimensional imaging of geological samples.  Analytical Chemistry 2015In Focus | DOI:10.1021/acs.analchem.5b01196
  3. Burger, M.; et al. High-speed, high-resolution, multi-elemental LA-ICP-TOFMS imaging: Part II. Critical evaluation of quantitative three-dimensional imaging of major, minor and trace elements in geological samples.  Analytical Chemistry 2015In Focus | DOI: 10.1021/acs.analchem.5b01977


  1. Borovinskaya, O.; et al. Simultaneous Mass Quantification of Nanoparticles of Different Composition in a Mixture by Microdroplet Generator-ICPTOFMS.  Analytical Chemistry 2014.  In Focus | DOI: 10.1021/ac501150c
  2. Borovinskaya, O.; et al. Diffusion- and velocity-driven spatial separation of analytes from single droplets entering an ICP off-axis.  J. Anal. At. Spectrom2014DOI: 10.1039/c3ja50307k


  1. Neubauer, U. Wie Forscher Nanopartikel in der Umwelt nachweisen. NZZ, 2013
  2. Borovinskaya, O.; et al. A prototype of a new inductively coupled plasma timeof-flight mass spectrometer providing temporally resolved, multi-element detection of short signals generated by single particles and droplets. J. Anal. At. Spectrom 2013DOI: 10.1039/C2JA30227F


  1. Tanner, M.; Günther, D. A new ICP–TOFMS. Measurement and readout of mass spectra with 30 µs time resolution, applied to in-torch LA–ICP–MS.  Anal Bioanal Chem 2008DOI: 10.1007/s00216-008-1869-3

Learn More

Airborne Particulate Matter

Element Analysis for Economic Geology

Elemental Imaging of Biological Tissue

Geological Laser Ablation Mapping

Gunshot Residue

Nanomaterial Toxicity

Nanoparticles in Materials

Nanoparticles in Soil

Nanoparticles in Water

Nuclear Security

Plant Tissue Analysis

Single-Cell Analysis

Thin Films Analysis